Hydrochloric Acid → HCID 178516515, compound

Reaction equation

C([O:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([N:10]2[CH2:14][CH2:13][CH:12]([OH:15])[CH2:11]2)[N:5]=1)C.Cl>>[OH:15][CH:12]1[CH2:13][CH2:14][N:10]([C:6]2[N:5]=[C:4]([OH:3])[CH:9]=[CH:8][N:7]=2)[CH2:11]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 595262421-(4-Ethoxypyrimidin-2-yl)pyrrolidin-3-ol

Product 1

HCID 178516515HCID 178516515, compound

Procedure

1-(4-Ethoxypyrimidin-2-yl)pyrrolidin-3-ol (1.0 g, 4.8 mol) was combined with 6M HCl (24 mL, 144 mmol) and heated to reflux overnight. The mixture was concentrated in vacuo to give the title compound.

Workup

temperatureheated
temperatureto reflux overnight
concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record: ord-6c4aae4efd6141c3b501918b973eafbe
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08367706B2

Reaction notes

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