Hydrochloric Acid → HCID 59332581, compound
Reaction equation
Cl.CC(OC([N:9]1[C:17]2[C:12](=[C:13]([F:21])[CH:14]=[CH:15][C:16]=2[C:18]([OH:20])=[O:19])[CH2:11][CH2:10]1)=O)(C)C>C(Cl)Cl>[F:21][C:13]1[CH:14]=[CH:15][C:16]([C:18]([OH:20])=[O:19])=[C:17]2[C:12]=1[CH2:11][CH2:10][NH:9]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 1 M HCl (1 mL, 1 mmol) was added to a solution of 1-{[(1,1-Dimethylethyl)oxy]carbonyl}-4-fluoro-2,3-dihydro-1H-indole-7-carboxylic acid (50 mg, x mmol) in DCM at room temperature. The reaction was stirred for 2 h, and additional 1 M HCl (1 mL, 1 mmol) was added. The reaction was stirred overnight, and the mixture was evaporated and dried under high vacuum, giving the title compound.
Workup
- stirringThe reaction was stirred overnight
- customthe mixture was evaporated
- customdried under high vacuum
Sources & evidence
- ORD record
- ord-87f98432cffb419290a7cdece8a942a1
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08372875B2
Reaction notes
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