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Ethanol → Ethyl 3-[2-fluoro-4-[[3-methoxy-4-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]propanoate

HRID 390404
Notes
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Reaction equation

HRID 390404 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH:8]=[CH:7]2)[CH2:3][CH2:2]1.C(N(CC)C(C)C)(C)C.[CH2:24]([O:26][C:27](=[O:51])[CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][C:33]([O:36][CH2:37][C:38]2[CH:43]=[CH:42][C:41]([CH2:44]Br)=[CH:40][C:39]=2C(F)(F)F)=[CH:32][C:31]=1[F:50])[CH3:25].C[CH2:53][OH:54]>>[F:50][C:31]1[CH:32]=[C:33]([O:36][CH2:37][C:38]2[CH:39]=[CH:40][C:41]([CH2:44][N:1]3[CH2:6][CH2:5][C:4]4([C:14]5[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=5)[CH:8]=[CH:7]4)[CH2:3][CH2:2]3)=[C:42]([O:54][CH3:53])[CH:43]=2)[CH:34]=[CH:35][C:30]=1[CH2:29][CH2:28][C:27]([O:26][CH2:24][CH3:25])=[O:51]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 4

HCID 702EthanolHCID 81531DiisopropylethylamineHCID 10330052Spiro[indene-1,4'-piperidine]HCID 670870493-[4-(4-Bromomethyl-2-trifluoromethyl-benzyloxy)-2-fluoro-phenyl]-propionic acid ethyl ester

Product 1

HCID 58230595Ethyl 3-[2-fluoro-4-[[3-methoxy-4-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]propanoate
Yield 47.7%

Conditions

Temperature
80 °C

Procedure

To a solution of spiro[indene-1,4′-piperidine] (0.515 g, 2.58 mmol) in EtOH (15 mL) is added N,N-diisopropylethylamine (1.4 mL, 2.589 mmol) and 3-[4-(4-bromomethyl-2-trifluoromethyl-benzyloxy)-2-fluoro-phenyl]-propionic acid ethyl ester (1.1 g, 2.58 mmol) at room temperature and the reaction mixture is stirred for 16 hours at 80° C. The mixture is concentrated, diluted with water, and extracted with EtOAc (2×50 mL). The combined extracts are washed with water (20 mL) and saturated brine (20 mL), dried over Na2SO4, filtered, and concentrated. The crude material is purified by silica gel column chromatography to give the title compound as a colorless gel (0.650 g, 47.7%). 1H NMR (400 MHz, CDCl3) δ 7.42-7.35 (m, 2H), 7.31-7.29 (d, J=8 Hz, 1H), 7.20-7.01 (m, 3H), 7.05 (s, 1H), 7.01-6.99 (d, J=8 Hz, 1H), 6.64-6.93 (d, J=4 Hz, 1H), 6.86-6.83 (d, J=12 Hz, 1H) 6.77 (s, 1H), 5.05 (s, 2H), 4.03-3.98 (m, 2H), 3.79 (s, 3H), 3.57 (s, 2H), 2.89-2.86 (d, J=12 Hz, 2H), 2.79-2.76 (t, J=8 Hz, 2H), 2.55-2.53 (d, J=8 Hz, 2H), 2.41-2.35 (t, J=12 Hz, 2H), 2.10-2.05 (t, J=8 Hz, 2H), 1.22-1.17 (t, J=8 Hz, 3H).

Workup

  1. concentrationThe mixture is concentrated
  2. additiondiluted with water
  3. extractionextracted with EtOAc (2×50 mL)
  4. washThe combined extracts are washed with water (20 mL) and saturated brine (20 mL)
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customThe crude material is purified by silica gel column chromatography

Sources & evidence

ORD record
ord-af27012965a9453d8c17b126f75a5a9b
Source dataset
uspto-grants-2013_02
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08383642B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes