N-(3-ethynylphenyl)acetamide → HCID 24952781, compound

HRID 391539

Reaction equation

HRID 391539 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][CH:8]=1)#[CH:2].Br[C:14]1[CH:15]=[N:16][CH:17]=[C:18]([CH:31]=1)[C:19]([N:21]=[S@@:22]([CH3:30])(=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:20]>>[C:10]([NH:9][C:5]1[CH:4]=[C:3]([C:1]#[C:2][C:14]2[CH:15]=[N:16][CH:17]=[C:18]([CH:31]=2)[C:19]([N:21]=[S@@:22]([CH3:30])(=[O:29])[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:20])[CH:8]=[CH:7][CH:6]=1)(=[O:12])[CH3:11]

Participants

3

Reactant 2

HCID 2726447N-(3-ethynylphenyl)acetamideHCID 86629466(S)-5-bromo-N-[methyl(oxido)phenyl--sulfanylidene]nicotinamide

Product 1

HCID 24952781HCID 24952781, compoundYield 67.8%

Procedure

In a manner similar to that described in Example 449, N-(3-ethynyl-phenyl)-acetamide (0.0469 g, 0.443 mmol) and (S)-5-bromo-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide (100 mg, 0.295 mmol) were reacted to give the title compound as a solid (83 mg, 0.20 mmol, 67%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-cf677d504d254127bdfaa6ad39fe3fe5
Source dataset
uspto-grants-2013_02
Patent number
US08383825B2

Linked notes

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