Thiazolidine → 2-Difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile

HRID 39223

Reaction equation

HRID 39223 reaction equation
[C:1]([C:3]1[C:8]([O:9][CH:10]([F:12])[F:11])=[CH:7][CH:6]=[CH:5][C:4]=1[S:13](Cl)(=[O:15])=[O:14])#[N:2].[S:17]1[CH2:21][CH2:20][NH:19][CH2:18]1>O1CCCC1>[F:11][CH:10]([F:12])[O:9][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]([S:13]([N:19]2[CH2:20][CH2:21][S:17][CH2:18]2)(=[O:15])=[O:14])[C:3]=1[C:1]#[N:2]

Participants

4

Reactant 2

HCID 10444ThiazolidineHCID 581007672-Cyano-3-difluoromethoxyphenylsulfonyl chloride

Product 1

HCID 441994412-Difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

54 mg of 2-cyano-3-difluoromethoxy-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 32 I of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by HPLC affords 35 mg of 2-difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile.

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customPurification by HPLC

Sources & evidence

ORD record
ord-4e03c46cba5d4544802825dfbdd6204e
Source dataset
uspto-grants-2013_09
Patent number
US08524896B2

Linked notes

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