Lithium Hydroxide → [Rac]-2-ethoxy-3-[2-methyl-4-[2-(5-methyl-2-phenyl-thiazol-4-yl)-ethoxy]-phenyl}-propionic acid

HRID 394236

Reaction equation

HRID 394236 reaction equation
C([O:3][C:4](=[O:32])[CH:5]([O:29][CH2:30][CH3:31])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[S:19][C:20]=2[CH3:21])=[CH:9][C:8]=1[CH3:28])C.[Li+].[OH-]>>[CH2:30]([O:29][CH:5]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[S:19][C:20]=2[CH3:21])=[CH:9][C:8]=1[CH3:28])[C:4]([OH:32])=[O:3])[CH3:31]

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 68616609[Rac]-2-ethoxy-3-{2-methyl-4-[2-(5-methyl-2-phenyl-thiazol-4-yl)-ethoxy]-phenyl]-propionic acid ethyl ester

Product 1

HCID 10002540[Rac]-2-ethoxy-3-[2-methyl-4-[2-(5-methyl-2-phenyl-thiazol-4-yl)-ethoxy]-phenyl}-propionic acid

Procedure

In analogy to the procedure described in example 10 d], [rac]-2-ethoxy-3-{2-methyl-4-[2-(5-methyl-2-phenyl-thiazol-4-yl)-ethoxy]-phenyl}-propionic acid ethyl ester was treated with LiOH to obtain [rac]-2-ethoxy-3-{2-methyl-4-[2-(5-methyl-2-phenyl-thiazol-4-yl)-ethoxy]-phenyl}-propionic acid as colorless solid.

Workup

  1. customdescribed in example 10 d

Sources & evidence

ORD record
ord-c20222cf626d456293cfc0de59de40f0
Source dataset
uspto-grants-2004_10
Patent number
US06809110B2

Linked notes

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