Hydrogen Bromide → 2,3,4,5-tetrahydro-1H-3-benzazepin-7-ol hydrobromide

HRID 395264

Reaction equation

C[O:2][C:3]1[CH:13]=[CH:12][C:6]2[CH2:7][CH2:8][NH:9][CH2:10][CH2:11][C:5]=2[CH:4]=1.[BrH:14]>>[BrH:14].[OH:2][C:3]1[CH:13]=[CH:12][C:6]2[CH2:7][CH2:8][NH:9][CH2:10][CH2:11][C:5]=2[CH:4]=1

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 138533487-Methoxy-2,3,4,5-tetrahydro-1h-3-benzazepine

Product 1

HCID 233313912,3,4,5-tetrahydro-1H-3-benzazepin-7-ol hydrobromide

Conditions

Temperature: 100 °C

Procedure

7-Methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine (10 g) in 48% aqueous hydrobromic acid (350 ml) was allowed to stir at 100° C. for 4 h. The mixture was cooled to 20° C. then evaporated to dryness in vacuo to give the title compound (14.5 g) as a brown solid.

Workup

temperatureThe mixture was cooled to 20° C.
customthen evaporated to dryness in vacuo

Sources & evidence

ORD record: ord-06c471aa95454f4dbe946f9057bfaef9
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06605607B1

Linked notes

Loading…