4-(Aminomethyl)Benzoic Acid → 4-[({3-[(2-Fluoro-4-iodophenyl)amino]isonicotinoyl}amino)methyl]benzoic acid

HRID 39551

Reaction equation

HRID 39551 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[NH2:19][CH2:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=1>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:19][CH2:20][C:21]1[CH:22]=[CH:23][C:24]([C:25]([OH:27])=[O:26])=[CH:28][CH:29]=1)=[O:14]

Participants

3

Reactant 2

HCID 655264-(Aminomethyl)Benzoic AcidHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2×

Product 1

HCID 117201254-[({3-[(2-Fluoro-4-iodophenyl)amino]isonicotinoyl}amino)methyl]benzoic acid

Procedure

4-[({3-[(2-fluoro-4-iodophenyl)amino]isonicotinoyl}amino)methyl]benzoic acid was synthesized according to the procedure for General Method 1, outlined above, starting with 0.3 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.45 mmol of 4-aminomethylbenzoic acid. LC/MS [9.25 min; 492 (M+1)]

Workup

  1. customLC/MS [9.25 min; 492 (M+1)]

Sources & evidence

ORD record
ord-42ed145d36574f8f872f590873590c04
Source dataset
uspto-grants-2013_09
Patent number
US08524911B2

Linked notes

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