4-Iodoaniline → 3-(4-Iodophenyl)amino-isonicotinic acid

Reaction equation

[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.F[C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][N:18]=1)[C:13]([OH:15])=[O:14]>>[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:16]2[CH:17]=[N:18][CH:10]=[CH:11][C:12]=2[C:13]([OH:15])=[O:14])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 108934-Iodoaniline

HCID 3453602-Fluoroisonicotinic acid

Product 1

HCID 117098523-(4-Iodophenyl)amino-isonicotinic acid

Procedure

3-(4-iodo-phenylamino)-isonicotinic acid was synthesized according to the procedure for General Method 1 and as Intermediate 1 by reacting 1.4 mmol of 4-iodoaniline with 2.8 mmol of 2-fluoro-isonicotinic acid LC/MS [6.29 min; 341 (M+1)].

Sources & evidence

ORD record: ord-410bb7ca4daf4f47b2f0dac7d3022dd4
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08524911B2

Reaction notes

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