1-Benzyl-3-(trifluoromethyl)piperidin-4-ol → HCID 23003698, compound
Reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH:10]([C:15]([F:18])([F:17])[F:16])[CH2:9]1)C1C=CC=CC=1>CO.[H][H].[OH-].[Pd+2].[OH-]>[OH:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH:10]1[C:15]([F:18])([F:16])[F:17]Participants
5
Reactant 1
Product 1
Reagents, catalysts & solvents 3
Procedure
A mixture of 1-benzyl-4-hydroxy-3-trifluoromethylpiperidine (1.8 g, 6.94 mmole and 20% palladium hydroxide (0.5 g) in methanol (25 ml) was stirred in hydrogen atmosphere (1.atm.) for 17 hr at 50° C. Catalyst was filtered off, washed with methanol, filtrate was concentrated to dryness to give 4-hydroxy-3-trifluoromethylpiperidine as oil. Yield 0.7 g (60%), C6H10F3NO, m/z 170 (M+1).
Workup
- filtrationCatalyst was filtered off
- washwashed with methanol, filtrate
- concentrationwas concentrated to dryness
Sources & evidence
- ORD record
- ord-18785e5a106b49ad8ad0274cab606b4b
- Source dataset
- uspto-grants-2003_08
- Patent number
- US06608078B2
Reaction notes
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