Sulfuric Acid → 4-(Bromomethyl)benzamide
Reaction equation
[Br:1][CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1.S(=O)(=O)(O)[OH:12]>>[Br:1][CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]([NH2:8])=[O:12])=[CH:5][CH:4]=1Participants
3
Procedure
A solution of 4-(bromomethyl)benzonitrile (500 mg, 2.55 mmol) in 90% sulphuric acid (8 ml) was heated at 100° C. for 1 h. The solution was carefully poured onto ice water (50 ml) and a precipitate formed. The solid was filtered, washed with water and diethyl ether and dried in vacuo to afford the title compound as a white solid (353 mg, 65%).
Workup
- additionThe solution was carefully poured onto ice water (50 ml)
- customa precipitate formed
- filtrationThe solid was filtered
- washwashed with water and diethyl ether
- customdried in vacuo
Sources & evidence
- ORD record
- ord-a547e8c3f82245a996fa8c4b3daf857d
- Source dataset
- uspto-grants-2003_08
- Patent number
- US06610711B2
Reaction notes
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