Acetic Acid → HCID 23445018, compound

HRID 397930

Reaction equation

HRID 397930 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1)[NH2:5].[CH:13](OCC)(OCC)OCC.[N+:23]([CH2:26]C(OCC)=O)([O-])=O.[C:32]([OH:35])(=[O:34])[CH3:33]>[Fe]>[F:1][C:2]1[CH:3]=[C:4]([N:5]2[CH:13]=[C:33]([C:32]([OH:35])=[O:34])[N:23]=[CH:26]2)[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

Participants

6

Reactant 4

HCID 176Acetic Acid2×HCID 31214Ethyl orthoformate2×HCID 69379Ethyl nitroacetateHCID 27359133-Amino-5-fluorobenzotrifluoride

Product 1

HCID 23445018HCID 23445018, compound

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Procedure

Following the general method described in example 234, 3-fluoro-5-trifluoromethylaniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The title compound was obtained as a white crystalline solid. Mp.>250° C. (H2O/dioxane), MS: m/e=273 (M−H−).

Sources & evidence

ORD record
ord-b147aa1cff6e43aeaab32b572cddd72d
Source dataset
uspto-grants-2003_08
Patent number
US06610723B2

Linked notes

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