Hydrochloric Acid → Pyridine, 2,4,6-trichloro-

To a mixture composed of 4-amino-2,6-dichloropyridine (5.5 g), cuprous chloride (4.4 g) and concentrated hydrochloric acid (50 ml), sodium nitrite (3.5 g) was added little by little under cooling with ice and sodium chloride. After the resultant mixture was stirred for one hour at the same temperature and for one and a half hour at a room temperature, water was added, and the mixture was extracted with chloroform. After the obtained extract was dried over anhydrous sodium sulfate, solvent was distilled off under reduced pressure to give 2,4,6-trichloropyridine (5.5 g).

1. additionwas added little by little
2. extractionthe mixture was extracted with chloroform
3. extractionAfter the obtained extract
4. dry with materialwas dried over anhydrous sodium sulfate, solvent
5. distillationwas distilled off under reduced pressure

ORD record

ord-36498c3c3f1340bab99605c8382e4339

Source dataset

uspto-grants-1998_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05817669