Piperazine → HCID 131718840, compound

HRID 399733

Reaction equation

HRID 399733 reaction equation
[C:1]([NH:4][C@H:5]([C:18]([OH:20])=[O:19])[CH2:6][S:7][S:8][CH2:9][C@H:10]([NH:14][C:15](=[O:17])[CH3:16])[C:11]([OH:13])=[O:12])(=[O:3])[CH3:2].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>O>[NH2+:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.[C:15]([NH:14][C@H:10]([C:11]([O-:13])=[O:12])[CH2:9][S:8][S:7][CH2:6][C@H:5]([NH:4][C:1](=[O:3])[CH3:2])[C:18]([O-:20])=[O:19])(=[O:17])[CH3:16]

Participants

4

Reactant 2

HCID 4837PiperazineHCID 6995101N,N'-Diacetyl-L-cystine

Product 1

HCID 131718840HCID 131718840, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To N,N'-diacetyl-L-cystine (4.60 mmole, 1.49 g) dissolved in 5 mL of water was added piperazine (4.60 mmole, 0.90 g). To the solution was added enough isopropanole to cause formation of an oil, which slowly solidifies. The salt was isolated and dried. Physical data: Mp >170° C. (dec.) 1H-NMR (D2O) δ: 2.05 [6H,s,CH3 ], 2.96 [2H,dd,CH2S], 3.26 [2H,dd,CH2S], 3.42 [8H,s,CH2 (2,3,5,6)], 4.49 [2H,dd,CHN]

Workup

  1. additionTo the solution was added enough isopropanole
  2. customThe salt was isolated
  3. customdried

Sources & evidence

ORD record
ord-d8e32015c1a74521bdc6954b216fce32
Source dataset
uspto-grants-1998_10
Patent number
US05824681

Linked notes

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