5'-Atp → S-carboxyl cysteine

HRID 399763

Reaction equation

[CH2:1]1[S:6][C:4](=[O:5])[NH:3][C@@H:2]1[C:7]([OH:9])=[O:8].P(OC[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2)[C@H](O)[C@@H]1O)(OP(OP(O)(O)=O)(O)=O)(=O)[OH:11]>>[C:4]([S:6][CH2:1][C@@H:2]([C:7]([OH:9])=[O:8])[NH2:3])([OH:11])=[O:5]

Participants

Reactant 2

HCID 59575'-Atp

HCID 72390Procysteine

Product 1

HCID 129672242S-carboxyl cysteine

Procedure

L-2-oxothiazolidine-4-carboxylate, in vitro, is subjected to the action of 5-oxo-L-prolinase in the presence of adenosine triphosphate to produce S-carboxyl cysteine. S-carboxyl cysteine is then decarboxylated to produce cysteine. Cysteine is then metabolized to provide glutathione. See, U.S. Pat. Nos.: 4,335,210; 4,434,158; 4,438,124; 4,665,082; and 4,647,571 the disclosures of which are incorporated herein by reference.

Sources & evidence

ORD record: ord-6592d8dcd3414e63b6bec7f250765eaf
Source dataset: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05824693

Linked notes

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