[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([C:16](=[O:22])[CH2:17]C(OC)=O)[CH:8]=[C:9]([N:11]2[CH:15]=[CH:14][CH:13]=[CH:12]2)[CH:10]=1)=[O:4].CO.S(=O)(=O)(O)O.C(OCC)(=O)C>O>[C:16]([C:7]1[CH:6]=[C:5]([CH:10]=[C:9]([N:11]2[CH:15]=[CH:14][CH:13]=[CH:12]2)[CH:8]=1)[C:3]([O:2][CH3:1])=[O:4])(=[O:22])[CH3:17]A solution of methyl 3-[3-methoxycarbonyl-5-(pyrrol-1-yl)phenyl]-3-oxopropionate (0.1 g) in a mixture of water (1 ml), methanol (3 ml) and concentrated sulfuric acid (40 mg) was refluxed for 16 hours. After being cooled to room temperature, the reaction mixture was poured into a mixture of ethyl acetate (50 ml) and water (50 ml). The organic layer was successively washed with a saturated aqueous sodium hydrogencarbonate solution and brine, dried over magnesium sulfate and evaporated in vacuo to afford methyl 3-acetyl-5-(pyrrol-1-yl)benzoate (20.1 mg).
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