Water → tert-Butyl 4-cyanopiperazine-1-carboxylate
Reaction equation
[C:1](Br)#[N:2].[C:4]([O:8][C:9]([N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)=[O:10])([CH3:7])([CH3:6])[CH3:5].CCN(C(C)C)C(C)C.O>ClCCl>[C:4]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:1]#[N:2])[CH2:13][CH2:12]1)=[O:10])([CH3:7])([CH3:5])[CH3:6]Participants
6
Conditions
- Temperature
- 0 °C
Procedure
3.76 g bromcyane was added to 6 g piperazine-1-carboxylic acid tert-butyl ester and 6.3 mL DIPEA in 30 mL dichlormethane at 0° C. The reaction was stirred 1.5 h at 0° C. Water and dichlormethane was added and the layers were separated. The organic layer was washed with brine and water and evaporated to give 6.8 g of the desired product.
Workup
- customthe layers were separated
- washThe organic layer was washed with brine and water
- customevaporated
Sources & evidence
- ORD record
- ord-2afb461737ab4519b1c24934a05f4261
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08741892B2
Reaction notes
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