Hydrazine → 3,5-bis(4-fluorophenyl)-1H-pyrazole

HRID 400484

Reaction equation

HRID 400484 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=O)=[CH:4][CH:3]=1.[NH2:20][NH2:21]>C1COCC1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[NH:21][N:20]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 738961,3-Propanedione, 1,3-bis(4-fluorophenyl)-

Product 1

HCID 161054793,5-bis(4-fluorophenyl)-1H-pyrazole

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
75 °C

Procedure

3.9 g 1,3-Bis-(4-fluoro-phenyl)-1,3-propandione was dissolved in 45 mL of a solution of 1 N hydrazine in THF and stirred for 2 h at 75° C. The solvent was removed to give 3.6 g of the desired compound. Rt: 1.03 min (method D), (M+H)+: 257

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-a728c573b75d463ea14b56975bd2d7d7
Source dataset
uspto-grants-2014_06
Patent number
US08741892B2

Linked notes

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