Iodocyclopentane → 6-(Cyclopentyloxy)-N-((5-fluoropyridin-3-yl)methyl)-2-isopropyl-1-(pyridin-3-ylmethyl)-1H-indole-3-carboxamide

HRID 40141

Reaction equation

HRID 40141 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][NH:9][C:10]([C:12]2[C:20]3[C:15](=[CH:16][C:17]([OH:21])=[CH:18][CH:19]=3)[N:14]([CH2:22][C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)[C:13]=2[CH:29]([CH3:31])[CH3:30])=[O:11])[CH:5]=[N:6][CH:7]=1.[CH:32]1(I)[CH2:36][CH2:35][CH2:34][CH2:33]1>>[CH:32]1([O:21][C:17]2[CH:16]=[C:15]3[C:20]([C:12]([C:10]([NH:9][CH2:8][C:4]4[CH:5]=[N:6][CH:7]=[C:2]([F:1])[CH:3]=4)=[O:11])=[C:13]([CH:29]([CH3:31])[CH3:30])[N:14]3[CH2:22][C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)=[CH:19][CH:18]=2)[CH2:36][CH2:35][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 73784IodocyclopentaneHCID 59762408N-((5-Fluoropyridin-3-yl)methyl)-6-hydroxy-2-isopropyl-1-(pyridin-3-ylmethyl)-1H-indole-3-carboxamide2×

Product 1

HCID 597624146-(Cyclopentyloxy)-N-((5-fluoropyridin-3-yl)methyl)-2-isopropyl-1-(pyridin-3-ylmethyl)-1H-indole-3-carboxamide

Procedure

The title compound was prepared from N-((5-fluoropyridin-3-yl)methyl)-6-hydroxy-2-isopropyl-1-(pyridin-3-ylmethyl)-1H-indole-3-carboxamide (Compound 162) and cyclopentyl iodide by General Procedure N.

Sources & evidence

ORD record
ord-674daa90c9d64af99e844d73d9c31a22
Source dataset
uspto-grants-2013_09
Patent number
US08524917B2

Linked notes

Loading…