HCID 23055952, compound → HCID 67254977, compound
Reaction equation
[CH2:1]([NH:4][C@@H:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH:6]1[Br:14])[CH:2]=[CH2:3].Br.CC(O)C>CC(OC)(C)C>[BrH:14].[CH2:1]([NH:4][C@@H:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH:6]1[Br:14])[CH:2]=[CH2:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 7.5 °C
Procedure
The obtained N-2-Propene-1-yl-2-bromo-(R)-aminoindan (5 g) in 100 ml of MTBE was added to 10 ml of 10% HBr/IPA solution and the reaction mixture was stirred at 5-10° C. for 30 min. The precipitated solid was filtered, washed with MTBE and dried to give 8.7 g of N-2-Propene-1-yl-2-bromo-(R)-aminoindan hydrobromide (90% yield). Mass spectrum: [M+1]+: 252
Workup
- filtrationThe precipitated solid was filtered
- washwashed with MTBE
- customdried
Sources & evidence
- ORD record
- ord-68e3db8ba0724da18daec6b71b19523a
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08741962B2
Reaction notes
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