Potassium Carbonate → HCID 66765091, compound

HRID 402756

Reaction equation

HRID 402756 reaction equation
C(=O)([O-])[O-].[K+].[K+].Cl.[C:8]1([NH:14][NH2:15])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.O=[C:17]([C:24]1[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:25]=1[F:32])[CH2:18][C:19](OCC)=[O:20]>CCO>[C:8]1([N:14]2[C:19](=[O:20])[CH2:18][C:17]([C:24]3[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:25]=3[F:32])=[N:15]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 60962Phenylhydrazine hydrochlorideHCID 2758933Ethyl 2,4,5-trifluorobenzoylacetate

Product 1

HCID 66765091HCID 66765091, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

Potassium carbonate (153 mg, 1.10 mmol) was added to a stirred mixture of phenyl hydrazine HCl salt (160 mg, 1.10 mmol) and ethyl 3-oxo-3-(2,4,5-trifluorophenyl)propanoate (272 mg, 1.10 mmol) in EtOH (6 mL) and the mixture was heated at 70° C. for 1 hour. The solution was cooled to room temperature and was concentrated to give the title compound, which was taken on to the next step.

Workup

  1. temperatureThe solution was cooled to room temperature
  2. concentrationwas concentrated

Sources & evidence

ORD record
ord-3b8aeac09dcf44bfbc8b68645c6200f3
Source dataset
uspto-grants-2014_06
Patent number
US08742110B2

Linked notes

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