HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-phenoxyphenyl isocyanate → (S)-Methyl 2-(6-(5-(3-(4-chloro-2-phenoxyphenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-phenoxyphenyl isocyanate | HCID 3407433 | — |
| Reactant | (S)-Methyl 2-(6-(5-aminopyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731548 | — |
| Reactant | (S)-Methyl 2-(6-(5-(3-(2-chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731549 | — |
| Product | (S)-Methyl 2-(6-(5-(3-(4-chloro-2-phenoxyphenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 53302548 | — |
Reaction Steps
The compound of example 395 was prepared analogous to the compound of example 393 by reaction of the compound of example 392 with 4-chloro-2-phenoxy phenyl isocyanate. The compound of example 395 was used directly for the preparation of compound of example 396 without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-926b1bc0a62943419c5534de587990fb |
| Source note | uspto-grants-2014_06 |