HRID403987

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3407433

4-Chloro-2-phenoxyphenyl isocyanate

C13H8ClNO2

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cn3)cc2C1=O

HCID131731548

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)Nc4ccccc4Cl)cn3)cc2C1=O

HCID131731549

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)Nc4ccc(Cl)cc4Oc4ccccc4)cn3)cc2C1=O

HCID53302548

未命名化合物

PROCEDURE

实验过程

The compound of example 395 was prepared analogous to the compound of example 393 by reaction of the compound of example 392 with 4-chloro-2-phenoxy phenyl isocyanate. The compound of example 395 was used directly for the preparation of compound of example 396 without purification.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-926b1bc0a62943419c5534de587990fb
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

ClC1C=CC=CC=1[NH:8][C:9](=[O:35])[NH:10][C:11]1[CH:12]=[CH:13][C:14]([C:17]2[CH:25]=[C:24]3[C:20]([CH2:21][N:22]([C@@H:27]([CH:32]([CH3:34])[CH3:33])[C:28]([O:30][CH3:31])=[O:29])[C:23]3=[O:26])=[CH:19][CH:18]=2)=[N:15][CH:16]=1.NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=NC=1.[Cl:61][C:62]1[CH:67]=[CH:66][C:65](N=C=O)=[C:64]([O:71][C:72]2[CH:77]=[CH:76][CH:75]=[CH:74][CH:73]=2)[CH:63]=1>>[Cl:61][C:62]1[CH:67]=[CH:66][C:65]([NH:8][C:9](=[O:35])[NH:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3[CH:25]=[C:24]4[C:20]([CH2:21][N:22]([C@@H:27]([CH:32]([CH3:34])[CH3:33])[C:28]([O:30][CH3:31])=[O:29])[C:23]4=[O:26])=[CH:19][CH:18]=3)=[N:15][CH:16]=2)=[C:64]([O:71][C:72]2[CH:73]=[CH:74][CH:75]=[CH:76][CH:77]=2)[CH:63]=1