4-Pentylbenzoyl chloride → Methyl 2-methyl-2-(1-oxo-6-(4-(4-pentylbenzamido)phenyl)isoindolin-2-yl)propanoate

HRID 404041

Reaction equation

HRID 404041 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[NH2:34][C:35]1[CH:40]=[CH:39][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([C:51]([CH3:57])([CH3:56])[C:52]([O:54][CH3:55])=[O:53])[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:37][CH:36]=1.[CH2:58]([C:63]1[CH:71]=[CH:70][C:66]([C:67](Cl)=[O:68])=[CH:65][CH:64]=1)[CH2:59][CH2:60][CH2:61][CH3:62]>>[CH3:56][C:51]([N:46]1[CH2:45][C:44]2[C:48](=[CH:49][C:41]([C:38]3[CH:37]=[CH:36][C:35]([NH:34][C:67](=[O:68])[C:66]4[CH:70]=[CH:71][C:63]([CH2:58][CH2:59][CH2:60][CH2:61][CH3:62])=[CH:64][CH:65]=4)=[CH:40][CH:39]=3)=[CH:42][CH:43]=2)[C:47]1=[O:50])([CH3:57])[C:52]([O:54][CH3:55])=[O:53]

Participants

4

Reactant 3

HCID 1708124-Pentylbenzoyl chlorideHCID 67307528HCID 67307528, compoundHCID 123625862(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67306977Methyl 2-methyl-2-(1-oxo-6-(4-(4-pentylbenzamido)phenyl)isoindolin-2-yl)propanoateYield 93%

Procedure

The compound of example 524 was prepared analogous to compound of example 97 by reaction of compound of example 515 with 4-(n-pentyl)-benzoyl chloride.

Sources & evidence

ORD record
ord-6051875c64624f378a0b1b19294d922d
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Linked notes

Loading…