2-Phenylglycine → HCID 86688926, compound

Temperature

0 °C

2-Amino-2-phenylacetic acid (1.00 g, 6.62 mmol) and TEA (2.77 ml, 19.8 mmol) were dissolved in a mixture of dioxane (13.2 ml) and water (13.2 ml). The mixture was cooled at 0° C. with an ice-bath and 4-chlorobutanoyl chloride (814 μl, 7.28 mmol) was added dropwise. The mixture was stirred at the same temperature for 1 hour and then dioxane was evaporated. The aqueous solution was acidified with 1N HCl and then was extracted three times with EtOAc (20 ml×3). The organic phase was dried (Na2SO4) and evaporated. The crude pale yellow oil was purified by flash chromatography (DCM/MeOH=9/1) and the collected compound was triturated with Et2O (about 15 ml) to obtain the title compound (658 mg, 38.9% yield) as a white solid.

1. customdioxane was evaporated
2. extractionwas extracted three times with EtOAc (20 ml×3)
3. dry with materialThe organic phase was dried (Na2SO4)
4. customevaporated
5. customThe crude pale yellow oil was purified by flash chromatography (DCM/MeOH=9/1)
6. customthe collected compound was triturated with Et2O (about 15 ml)

ORD record

ord-27a511d631f44ac1a685c2fde43c258e

Source dataset

uspto-grants-2014_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08748613B2