HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → N-((1S)-1-(4-Bromophenyl)ethyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | (alphaS)-4-Bromo-alpha-methylbenzenemethanamine | HCID 852999 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-((1S)-1-(4-Bromophenyl)ethyl)acetamide | HCID 793484 | — |
Reaction Steps
23.6 mL (250 mmol) acetic anhydride are added to 50.0 g (250 mmol) (S)-1-(4-bromophenyl)-ethylamine in 200 mL DCM while keeping the reaction temperature below 30° C. Stirring is continued for 12 h at rt. After that time, saturated NaHCO3-solution is added. The organic layer is separated, washed with water, dried over magnesium sulphate and the solvent is removed by evaporation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530461B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-f96979fe72f74084b61a860b344e7a4f |
| Source note | uspto-grants-2013_09 |