反应详情

23.6 mL (250 mmol) acetic anhydride are added to 50.0 g (250 mmol) (S)-1-(4-bromophenyl)-ethylamine in 200 mL DCM while keeping the reaction temperature below 30° C. Stirring is continued for 12 h at rt. After that time, saturated NaHCO3-solution is added. The organic layer is separated, washed with water, dried over magnesium sulphate and the solvent is removed by evaporation.

1. customthe reaction temperature below 30° C
2. customThe organic layer is separated
3. washwashed with water
4. dry with materialdried over magnesium sulphate
5. customthe solvent is removed by evaporation