Ammonia → Hydroxyamfetamine

HRID 40556

Reaction equation

HRID 40556 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=O)[CH3:10])=[CH:4][CH:3]=1.[NH3:12].[H][H]>CO.[Ni]>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH2:12])[CH3:10])=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 222AmmoniaHCID 70192744-HydroxyphenylacetoneHCID 178418361HCID 178418361, compound

Product 1

HCID 3651Hydroxyamfetamine

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A mixture of 7.00 g (46.6 mmol) 4-hydroxyphenylacetone and 200 mL 7N ammonia in MeOH is charged with 0.70 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (50 psi) at r.t. over night. After complete reaction, the mixture is filtrated, the solvent is removed in vacuo and the crude product is purified by HPLC (MeOH/H2O/NH3).

Workup

  1. customAfter complete reaction
  2. filtrationthe mixture is filtrated
  3. customthe solvent is removed in vacuo
  4. customthe crude product is purified by HPLC (MeOH/H2O/NH3)

Sources & evidence

ORD record
ord-cb14c09e723444f6967e7938a6ec22f0
Source dataset
uspto-grants-2013_09
Patent number
US08530460B2

Linked notes

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