HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Hydroxyamfetamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Hydroxyphenylacetone | HCID 7019274 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Hydroxyamfetamine | HCID 3651 | — |
Reaction Steps
A mixture of 7.00 g (46.6 mmol) 4-hydroxyphenylacetone and 200 mL 7N ammonia in MeOH is charged with 0.70 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (50 psi) at r.t. over night. After complete reaction, the mixture is filtrated, the solvent is removed in vacuo and the crude product is purified by HPLC (MeOH/H2O/NH3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530460B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-cb14c09e723444f6967e7938a6ec22f0 |
| Source note | uspto-grants-2013_09 |