Hydrogen Bromide → HCID 49758827, compound

HRID 40557Notes

Reaction equation

HRID 40557 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([NH2:11])[CH3:10])=[CH:5][CH:4]=1.[BrH:12]>>[BrH:12].[NH2:11][C@H:9]([C:6]1[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=1)[CH3:10]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 793467(S)-1-(4-Methoxyphenyl)ethylamine

Product 1

HCID 49758827HCID 49758827, compound

Conditions

Temperature
100 °C

Procedure

To 11.0 g (72.7 mmol) (S)-1-(4-methoxy-phenyl)-ethylamine is added carefully 30 mL HBr (30% in HOAc). The mixture is stirred at 100° C. for 4 h. After cooling down to r.t., the solvent is removed in vacuo and the residue is dried in vacuo. The resulting product is used without further purification.

Workup

  1. temperatureAfter cooling down to r.t.
  2. customthe solvent is removed in vacuo
  3. customthe residue is dried in vacuo
  4. customThe resulting product is used without further purification

Sources & evidence

ORD record
ord-388579f90eae45a381a7f25c01287e36
Source dataset
uspto-grants-2013_09
Patent number
US08530460B2

Reaction notes

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