Phosphorus oxychloride → 5-(Tert-butyl)-2-chloropyrimidine

Reaction equation

[C:1]([C:5]1[CH:6]=[N:7][C:8](=O)[NH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].O=P(Cl)(Cl)[Cl:14]>>[C:1]([C:5]1[CH:6]=[N:7][C:8]([Cl:14])=[N:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 149435945-(tert-butyl)pyrimidin-2(1H)-one

Product 1

HCID 149435955-(Tert-butyl)-2-chloropyrimidine

Procedure

200 mL POCl3 and 14 g (0.09 mol) 5-tert-butylpyrimidin-2(1H)-one are heated in a sealed glass ampoule for 3 h at 160° C. The mixture is cooled and the excess

Workup

temperatureThe mixture is cooled

Sources & evidence

ORD record: ord-e6544b0204d542119421404452d51507
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08530460B2

Reaction notes

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