Methylamine → n-Methyl-3-nitropyridin-4-amine
Reaction equation
CO[C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[N+:9]([O-:11])=[O:10].[CH3:12][NH2:13]>C(O)C>[CH3:12][NH:13][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[N+:9]([O-:11])=[O:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2.36 g 4-methoxy-3-nitro-pyridine and 2.33 ml methylamine (40% in water) are refluxed in 25 ml of ethanol for 3 h. Then the reaction mixture is evaporated to dryness. 2.3 g product are obtained as a solid.
Workup
- customThen the reaction mixture is evaporated to dryness
Sources & evidence
- ORD record
- ord-35e601a38c5e47dfb5ec3c8613cdef1f
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08754073B2
Reaction notes
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