Hydrochloric Acid → HCID 178475043, compound
Reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:10][CH:9]1[NH:11][C:12]([C:14]1[S:39][C:17]2[N:18]=[CH:19][N:20]=[C:21]([NH:22][C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=3[O:30][C@H:31]3[CH2:34][C@H:33]([NH:35][C:36](=[O:38])[CH3:37])[CH2:32]3)[C:16]=2[C:15]=1[CH3:40])=[O:13])(C)(C)C.Cl>O1CCOCC1>[NH2:7][CH:8]1[CH2:10][CH:9]1[NH:11][C:12]([C:14]1[S:39][C:17]2[N:18]=[CH:19][N:20]=[C:21]([NH:22][C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=3[O:30][C@H:31]3[CH2:32][C@H:33]([NH:35][C:36](=[O:38])[CH3:37])[CH2:34]3)[C:16]=2[C:15]=1[CH3:40])=[O:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 0.15 g [2-({4-[2-(trans-3-acetylamino-cyclobutoxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carbonyl}amino)-cyclopropyl]-carbamic acid tert-butyl ester in 5 ml dioxane was added 1 M hydrochloric acid solution in Dioxan and was stirred at rt overnight. The reaction mixture was concentrated and the residue was purified by chromatography.