2-Isopropylpyridine → 1-Oxo-2-(propan-2-yl)-1lambda~5~-pyridine
Reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1)([CH3:3])[CH3:2].C1C=C(Cl)C=C(C(OO)=[O:18])C=1>C(Cl)Cl>[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N+:5]=1[O-:18])([CH3:3])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of isopropylpyridine (2.1 g, 17.75 mmol) and m-CPBA (5.0 g, 1.3 eq.) in CH2Cl2 was stirred overnight at room temperature. Then, the reaction mixture was diluted with CH2Cl2 (twice the volume) and successively washed with aqueous sodium bicarbonate (twice) and brine, dried (Na2SO4) and evaporated to give 2.0 g (85%) of the title compound 104.
Workup
- washsuccessively washed with aqueous sodium bicarbonate (twice) and brine
- dry with materialdried (Na2SO4)
- customevaporated
Sources & evidence
- ORD record
- ord-3b5a2279c0dd4dc4be59883f719edeea
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08754106B2
Reaction notes
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