Piperazine → HCID 59606520, compound
Reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[CH:6][C:7]=1Cl.[NH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>C(O)C>[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[CH:6][C:7]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
18 g 3,4,6-trichloro-pyridazine and 34 g piperazine are suspended in 100 ml of ethanol and stirred for 30 minutes at ambient temperature. The precipitated solid is suction filtered. 500 ml of water are added to the mother liquor and the precipitated product is suction filtered. 14 g product are obtained in the form of a solid. M.p.=111-115° C.
Workup
- filtrationfiltered
- addition500 ml of water are added to the mother liquor
- filtrationfiltered
Sources & evidence
- ORD record
- ord-9d241223fb804413b87f939444258d17
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08759326B2
Reaction notes
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