1,3-Cyclohexanedione → HCID 178428409, compound

Reaction equation

[C:1]1(=[O:8])[CH2:6][CH2:5][CH2:4][C:3](=O)[CH2:2]1.[CH3:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16](/[CH:19]=[C:20](/[C:23](=O)[CH3:24])\[C:21]#[N:22])[CH:17]=2)[NH:12][N:11]=1.C([O-])(=O)C.[NH4+:30]>C(O)(=O)C>[CH3:24][C:23]1[NH:30][C:3]2[CH2:4][CH2:5][CH2:6][C:1](=[O:8])[C:2]=2[CH:19]([C:16]2[CH:17]=[C:18]3[C:13](=[CH:14][CH:15]=2)[NH:12][N:11]=[C:10]3[CH3:9])[C:20]=1[C:21]#[N:22]

Participants

Procedure

273 mg (2.442 mmol) cyclohexane-1,3-dione, 500 mg (2.222 mmol) (2E)-2-[(3-methyl-1H-indazol-5-yl)methylidene]-3-oxobutanenitrile (Example 2A) and 205 mg (2.664 mmol) ammonium acetate in acetic acid (5 ml) were heated to 50° C. overnight. Then, additional ammonium acetate (102 mg, 1.332 mmol) was added, and the mixture was heated to reflux for 24 h. After cooling, the mixture was evaporated to dryness, and the residue was taken up in ethyl acetate and washed with water twice. The combined aqueous phases were extracted with ethyl acetate. The organic layers were combined and dried over sodium sulfate. After filtration and evaporation to dryness, the remaining solid was purified by preparative RP-HPLC (acetonitrile/water gradient) to yield 55 mg (8% of th.) of the title compound.