Hydrochloric Acid → 3,5-Diamino-6-chloro-pyrazine acid

HRID 408640

Reaction equation

HRID 408640 reaction equation
[NH2:1][C:2]1[C:3]([C:10]([O:12]C)=[O:11])=[N:4][C:5]([Cl:9])=[C:6]([NH2:8])[N:7]=1.CO.[OH-].[Na+].Cl>O>[NH2:1][C:2]1[C:3]([C:10]([OH:12])=[O:11])=[N:4][C:5]([Cl:9])=[C:6]([NH2:8])[N:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 73827Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate

Product 1

HCID 64521193,5-Diamino-6-chloro-pyrazine acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (100 g; 494 mmol), methanol (1 l) and NaOH (6 mol/l in water; 240 mL; 1.44 mol) is refluxed for 3 h. The mixture is allowed to cool to r.t. and then neutralized by addition of hydrochloric acid (6 mol/l in water; approx. 240 mL). Water (200 mL) is added. The precipitate formed is filtered off with suction, washed with water and dried at 60° C.

Workup

  1. temperatureis refluxed for 3 h
  2. customThe precipitate formed
  3. filtrationis filtered off with suction
  4. washwashed with water
  5. customdried at 60° C.

Sources & evidence

ORD record
ord-5d57ac059a32472f9c870d0f357b9a33
Source dataset
uspto-grants-2014_06
Patent number
US08759349B2

Linked notes

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