Hydrochloric Acid → N-Ethyl-2-(4-piperidin-4-yl-phenyl)-propionamide hydrochloride
Reaction equation
[ClH:1].[CH2:2]([NH:4][C:5](=[O:20])[CH:6]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:10][CH:9]=1)[CH3:7])[CH3:3]>O1CCOCC1>[ClH:1].[CH2:2]([NH:4][C:5](=[O:20])[CH:6]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:10][CH:9]=1)[CH3:7])[CH3:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
N-Ethyl-2-(4-piperidin-4-yl-phenyl)-propionamide hydrochloride is obtained by adding 4N HCl in dioxane to N-ethyl-2-(4-piperidin-4-yl-phenyl)-propionamide (VI.1). The mixture is stirred for 1 h and the solvent is removed in vacuo. The residue is taken up in diethyl ether, stirred for 20 min and the solvent is evaporated to yield the desired product.