Ammonia → Ethyl 4-amino-2-fluoro-5-nitrobenzoate
Reaction equation
[F:1][C:2]1[CH:12]=[C:11](F)[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH3:17]>C1COCC1>[F:1][C:2]1[CH:12]=[C:11]([NH2:17])[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of ethyl 2,4-difluoro-5-nitro-benzoate (5.0 g, 21 mmol), 5.2 mL conc. NH3 and THF (25 mL) is stirred for 30 min in an ice bath and overnight at rt. The mixture is concentrated and diluted with water. The precipitate is filtered, washed with water and dried at 55° C. to furnish the crude sub-title compound.
Workup
- concentrationThe mixture is concentrated
- additiondiluted with water
- filtrationThe precipitate is filtered
- washwashed with water
- customdried at 55° C.
Sources & evidence
- ORD record
- ord-5adf13836dd14585ac25c36bd8c0db63
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08759537B2
Reaction notes
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