Dichloromethane → (R)-1-((R)-3-Amino-pyrrolidin-1-yl)-propan-2-ol dihydrochloride
Reaction equation
C(OC(=O)[NH:7][C@@H:8]1[CH2:12][CH2:11][N:10]([CH2:13][C@H:14]([OH:16])[CH3:15])[CH2:9]1)(C)(C)C.C(Cl)[Cl:19]>Cl.O1CCOCC1>[ClH:19].[ClH:19].[NH2:7][C@@H:8]1[CH2:12][CH2:11][N:10]([CH2:13][C@H:14]([OH:16])[CH3:15])[CH2:9]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
(R)-1-((R)-3-Amino-pyrrolidin-1-yl)-propan-2-ol dihydrochloride (140 mg) was prepared by following General Procedure L starting from [(R)-1-((R)-2-hydroxy-propyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester (244 mg) and DCM (2 mL) in 4M HCl in dioxane (2 mL).
Sources & evidence
- ORD record
- ord-482f71f4e97d4f198dba6df2445a7e1d
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08759535B2
Reaction notes
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