2-Fluoro-5-methylbenzonitrile → 1-(3-Cyano-4-fluorobenzyl)-5-imidazolecarboxaldehyde

HRID 412146

Reaction equation

HRID 412146 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH3:10])[CH:6]=[CH:7][C:8]=1[F:9])#[N:2].C(C1C=CC(C[N:18]2[C:22]([CH:23]=[O:24])=[CH:21][N:20]=[CH:19]2)=CC=1F)#N>>[C:1]([C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][C:8]=1[F:9])[CH2:10][N:18]1[C:22]([CH:23]=[O:24])=[CH:21][N:20]=[CH:19]1)#[N:2]

Participants

3

Reactant 2

HCID 27745842-Fluoro-5-methylbenzonitrile2×HCID 11424708HCID 11424708, compound

Product 1

HCID 185360661-(3-Cyano-4-fluorobenzyl)-5-imidazolecarboxaldehyde

Procedure

The titled product was prepared from 3-cyano-4-fluorotoluene using the same procedures as those described in Example 1, Steps D through G for the preparation of 1-(4-cyano-3-fluorobenzyl)-5-imidazolecarboxaldehyde, except that 3-cyano-4-fluorotoluene was used in place of 4-cyano-3-fluorotoluene in Step D.

Sources & evidence

ORD record
ord-b86c9e3f6f9c46cda827c3bd970098be
Source dataset
uspto-grants-2003_05
Patent number
US06562823B1

Linked notes

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