1,1'-Carbonyldiimidazole → HCID 15484057, compound
Reaction equation
[F:1][C:2]([F:15])([F:14])[S:3]([C:6]1[CH:7]=[C:8]([NH2:13])[C:9]([NH2:12])=[CH:10][CH:11]=1)(=[O:5])=[O:4].C1N=CN([C:21](N2C=NC=C2)=[O:22])C=1>CC#N>[F:15][C:2]([F:14])([F:1])[S:3]([C:6]1[CH:11]=[CH:10][C:9]2[NH:12][C:21](=[O:22])[NH:13][C:8]=2[CH:7]=1)(=[O:4])=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Reflux 4-trifluoromethylsulfonyl-benzene-1,2-diamine (420 mg) and CDI (284 mg) for 16 hours in CH3CN (30 mL). Evaporate the solvent in vacuo. Purify by flash chromatography (1:1 hexanes/EtOAc) to obtain 5-trifluoromethylsulfonyl-1,3-dihydro-benzimidazol-2-one.
Workup
- customEvaporate the solvent in vacuo
- customPurify by flash chromatography (1:1 hexanes/EtOAc)
Sources & evidence
- ORD record
- ord-b8635cf9297b484db8243aa3db62d5d2
- Source dataset
- uspto-grants-2003_05
- Patent number
- US06566367B2
Reaction notes
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