Bromine → p-Bromophenoxyethanol

Temperature

15 °C

Phenoxyethanol (440 g, 3.1874 mol) was dissolved in 880 ml of a mixed solution of acetic acid/water =7/3. Sodium acetate (340 g, 4.1436 mol) was added and cooled to 15° C. A solution resulting from dissolving bromine (514.5 g, 3.22 mol) in 1760 ml of a mixed solution of acetic acid/water=7/3 was dropped while keeping at 15-20° C. and then was stirred at 10-20° C. for 30 minutes. Yellow color remained a little. Six milliliter of a 10 W/W% aqueous sodium sulfite solutions was dropped. The mixture became colorless. Dropping 2200 ml of water caused clouding. Crystallization was conducted by addition of seed crystals and stirring at room temperature for 30 minutes. After adding 4400 ml of water, stirring was done at room temperature for 30 minutes and at 0-10° C. for 1.5 hours. The crystals were filtered and washed with 3 L of water. After overnight air-drying and vacuum drying (35-40° C.) for 16 hours, 631 g (Yield 91.3%) of p-bromophenoxyethanol was obtained as white crystals.

1. customA solution resulting
2. additionwas dropped
3. customwhile keeping at 15-20° C.
4. customCrystallization
5. additionwas conducted by addition of seed crystals
6. stirringstirring at room temperature for 30 minutes
7. additionAfter adding 4400 ml of water
8. stirringstirring
9. waitwas done at room temperature for 30 minutes and at 0-10° C. for 1.5 hours
10. filtrationThe crystals were filtered
11. washwashed with 3 L of water
12. customAfter overnight air-drying
13. customvacuum drying (35-40° C.) for 16 hours

ORD record

ord-cb43acf0896d493bb56e50dddd3a66b6

Source dataset

uspto-grants-2003_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06566535B1