Hydrochloric Acid → HCID 21280962, compound

HRID 414529

Reaction equation

HRID 414529 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][C:10]2[CH:15]=[C:14]([O:16][CH3:17])[C:13]([NH2:18])=[C:12]([O:19][CH3:20])[CH:11]=2)=[CH:4][N:3]=1.[ClH:21]>CO>[ClH:21].[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][C:10]2[CH:11]=[C:12]([O:19][CH3:20])[C:13]([NH2:18])=[C:14]([O:16][CH3:17])[CH:15]=2)=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 176875Aditeren

Product 1

HCID 21280962HCID 21280962, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2.75 g. of 2,4-diamino-5-(4-amino-3,5-dimethoxy-benzyl)pyrimidine in 50 ml. of methanol was treated with 10 ml. of 1N hydrochloric acid. The resulting precipitate was dissolved by warming and the solution evaporated at 60° C. under vacuum to about 20 ml. After standing at room temperature for 2 hours, the precipitate was removed by filtration with suction, washed with methanol and dried, whereby there was obtained 2,4-diamino-5-(4-amino-3,5-dimethoxybenzyl)-pyrimidine hydrochloride having a melting point of 296° C. (decomposition).

Workup

  1. dissolutionThe resulting precipitate was dissolved
  2. temperatureby warming
  3. customthe solution evaporated at 60° C. under vacuum to about 20 ml
  4. customthe precipitate was removed by filtration with suction
  5. washwashed with methanol
  6. customdried

Sources & evidence

ORD record
ord-5785db65484441c1a4b57ae571590bfc
Source dataset
uspto-grants-1988_12
Patent number
US04792557

Linked notes

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