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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 416062Generated: October 26, 2026

Trifluoroacetic acid → 2-(4-(3-(4-Iodobenzyloxy)-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-2,3-dichlorophenoxy)-2-methylpropanoic acid

https://huagongshe.com/reaction/416062

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantTert-butyl 2-(4-(3-(4-iodobenzyloxy)-3-(5-(4-(trifluoromethyl) phenyl)thien-2-yl)propyl)-2,3-dichlorophenoxy)-2-methylpropanoateHCID 25062867—
Product2-(4-(3-(4-Iodobenzyloxy)-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-2,3-dichlorophenoxy)-2-methylpropanoic acidHCID 25062868—

Reaction Steps

2-(4-(3-(4-Iodobenzyloxy)-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-2,3-dichlorophenoxy)-2-methylpropanoic acid is prepared from tert-butyl 2-(4-(3-(4-iodobenzyloxy)-3-(5-(4-(trifluoromethyl) phenyl)thien-2-yl)propyl)-2,3-dichlorophenoxy)-2-methylpropanoate according to general procedure E using 10 equivalents of trifluoroacetic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08088819B2
Source datasetuspto-grants-2012_01
ORD IDord-bebd83614f7a484495864e3595c3ce8c
Source noteuspto-grants-2012_01