HRID416062

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)C(C)(C)Oc1ccc(CCC(OCc2ccc(I)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)s2)c(Cl)c1Cl

HCID25062867

未命名化合物

PRODUCTS

生成物

结构：CC(C)(Oc1ccc(CCC(OCc2ccc(I)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)s2)c(Cl)c1Cl)C(=O)O

HCID25062868

未命名化合物

PROCEDURE

实验过程

2-(4-(3-(4-Iodobenzyloxy)-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-2,3-dichlorophenoxy)-2-methylpropanoic acid is prepared from tert-butyl 2-(4-(3-(4-iodobenzyloxy)-3-(5-(4-(trifluoromethyl) phenyl)thien-2-yl)propyl)-2,3-dichlorophenoxy)-2-methylpropanoate according to general procedure E using 10 equivalents of trifluoroacetic acid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bebd83614f7a484495864e3595c3ce8c
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08088819B2
来源说明: uspto-grants-2012_01

反应 SMILES

[I:1][C:2]1[CH:46]=[CH:45][C:5]([CH2:6][O:7][CH:8]([C:30]2[S:31][C:32]([C:35]3[CH:40]=[CH:39][C:38]([C:41]([F:44])([F:43])[F:42])=[CH:37][CH:36]=3)=[CH:33][CH:34]=2)[CH2:9][CH2:10][C:11]2[CH:27]=[CH:26][C:14]([O:15][C:16]([CH3:25])([CH3:24])[C:17]([O:19]C(C)(C)C)=[O:18])=[C:13]([Cl:28])[C:12]=2[Cl:29])=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>>[I:1][C:2]1[CH:46]=[CH:45][C:5]([CH2:6][O:7][CH:8]([C:30]2[S:31][C:32]([C:35]3[CH:36]=[CH:37][C:38]([C:41]([F:42])([F:44])[F:43])=[CH:39][CH:40]=3)=[CH:33][CH:34]=2)[CH2:9][CH2:10][C:11]2[CH:27]=[CH:26][C:14]([O:15][C:16]([CH3:25])([CH3:24])[C:17]([OH:19])=[O:18])=[C:13]([Cl:28])[C:12]=2[Cl:29])=[CH:4][CH:3]=1