Bromoacetic Acid → HCID 178418509, compound
Reaction equation
[SH:1][C:2]1[S:3][C:4]([SH:7])=[N:5][N:6]=1.[OH-].[K+].Br[CH2:11][C:12]([OH:14])=[O:13]>O>[C:12]([CH2:11][S:1][C:2]1[S:3][C:4]([SH:7])=[N:5][N:6]=1)([OH:14])=[O:13]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 60 °C
Procedure
In 200 ml of water were dissolved 15.0 g of 2,5-dimercapto-1,3,4-thiadiazole and 69 g of potassium hydroxide, and a solution of 13.9 g of bromoacetic acid in 30 ml of water was added thereto dropwise at room temperature. After the addition, the mixture was stirred at 60° C. for 1 hour, followed by allowing to cool to room temperature. The precipitated crystals were filtered and washed with water to obtain 18 g of the desired compound. Melting point: 161°-167° C.
Workup
- customdropwise at room temperature
- additionAfter the addition
- temperatureto cool to room temperature
- filtrationThe precipitated crystals were filtered
- washwashed with water
Sources & evidence
- ORD record
- ord-03c19910184945d28d0037efcffa7194
- Source dataset
- uspto-grants-1988_02
- Patent number
- US04724199
Reaction notes
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