Tert-butyl malonate → HCID 178515848, compound

HRID 41760

Reaction equation

HRID 41760 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[O:11]=[C:12]1[CH2:17][CH2:16][CH:15]([C:18]2[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=2)[CH2:14][CH2:13]1.[C:26](OC(C)(C)C)(=[O:31])[CH2:27][C:28]([O-])=[O:29].C(=O)(OC)OC(C)(C)C[N+]#[C-].CC(C)([O-])C.[Na+]>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:22]([C:21]4[CH:24]=[CH:25][C:18]([CH:15]5[CH2:16][CH2:17][C:12](=[O:11])[CH2:13][CH2:14]5)=[CH:19][CH:20]=4)[C:28](=[O:29])[CH2:27][C:26]3=[O:31])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

6

Reactant 5

HCID 21883978Tert-butyl malonateHCID 23676156Sodium t-butoxideHCID 252674641-Isocyano-2-methylpropan-2-yl methyl carbonateHCID 866708804-(4-Oxocyclohexyl)benzaldehydeHCID 178507353HCID 178507353, compound

Product 1

HCID 178515848HCID 178515848, compound

Procedure

The compound was synthesized starting from 1H-benzo[d]imidazol-5-amine (0.803 g, 6.04 mmol), 4-(4-oxocyclohexyl)benzaldehyde (1.5 g, 6.04 mmol), mono-tert-butyl malonate (0.97 g, 6.04 mmol), 1-isocyano-2-methylpropan-2-yl methyl carbonate (0.95 g, 6.04 mmol) and sodium tert.-butoxide (0.60 mg, 5.35 mmol) according to method 5.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-08d7ac3e2aaf4b138490cb7faa4c7e3b
Source dataset
uspto-grants-2013_09
Patent number
US08530670B2

Linked notes

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