2-Oxoglutaric Acid → 1,4,5,6-Tetrahydro-6-oxo-3-pyridazinecarboxylic acid

HRID 41802

Reaction equation

HRID 41802 reaction equation
[NH2:1][NH2:2].O=[C:4]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])[C:5](O)=[O:6]>>[O:6]=[C:5]1[NH:2][N:1]=[C:9]([C:10]([OH:12])=[O:11])[CH2:8][CH2:4]1

Participants

3

Reactant 2

HCID 512-Oxoglutaric AcidHCID 9321Hydrazine2×

Product 1

HCID 996211,4,5,6-Tetrahydro-6-oxo-3-pyridazinecarboxylic acidYield 99%

Procedure

The disclosed embodiments stem from the examination of several classes of compounds that quantitatively react with hydrazine to form stable organic products. The reaction of 2-ketoglutaric acid with hydrazine reacts to provide a greater than 99% yield of 6-oxo-1,4,5,6-tetrahydro-pyridazine-3-carboxylic acid (PCA) based on hydrazine as the limiting reagent. It has been found that this compound allows for the facile remediation of hydrazine under a variety of conditions. The focus of the disclosed embodiments concerns the use of 2-ketoglutaric acid or other dicarbonyl compounds for the remediation of hydrazine.

Workup

  1. customto form stable organic products
  2. customreacts

Sources & evidence

ORD record
ord-e3234c6d563d46798823285107d150ba
Source dataset
uspto-grants-2013_09
Patent number
US08535430B2

Linked notes

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