Phosphorus oxychloride → 4-Chloro-8-(difluoromethoxy)quinoline
Reaction equation
[F:1][CH:2]([F:15])[O:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[C:9]2O.P(Cl)(Cl)([Cl:18])=O>>[F:1][CH:2]([F:15])[O:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[C:9]2[Cl:18]Participants
3
Procedure
The product from step b) was heated to reflux in phosphorus oxychloride (80 ml) for 1 hour. The reagent was evaporated under reduced pressure to give an oil which was carefully poured into a mixture of ice/880 ammonia solution (400 ml) and stirred for 30 minutes. The solid was filtered off and dried in vacuo to give the sub-title compound (6.80 g).
Workup
- customThe reagent was evaporated under reduced pressure
- customto give an oil which
- filtrationThe solid was filtered off
- customdried in vacuo
Sources & evidence
- ORD record
- ord-b4394c2c00fa4d369689f08ced98c5be
- Source dataset
- uspto-grants-2012_01
- Patent number
- US08093278B2
Reaction notes
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